DIDS sodium salt

SKU: orb1217745

Description

DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.

Key Properties

• CAS Number: 67483-13-0
• MW: 498.48
• Purity: >98% (HPLC)
• Formula: C₁₆H₈N₂Na₂O₆S₄
• SMILES: C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])/C=C/C2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
• Target: ABC
• Solubility: DMSO:50 mg/mL (100.30 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MDL101114ZA

Quick Database Links

Gene Symbol

ABC