Dictamine

SKU: orb1301529

Description

Dictamine is a natural alkaloid with documented anticholinesterase, antimicrobial, and anti-inflammatory properties. Its cytotoxic effects against human carcinoma cell lines, such as cervical, colon, and oral cancers, make it a compound of interest for in vitro pharmacological and oncology research.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 484-29-7
• MW: 199.21
• Purity: 99.72% (May vary between batches)
• Formula: C₁₂H₉NO₂
• SMILES: COc1c2ccoc2nc2ccccc12
• Target: Anti-infection|||Apoptosis|||Antifungal|||Antibacterial
• Solubility: DMSO:50 mg/mL (250.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.04 mM)

Bioactivity

• In Vivo:
  Dictamnine showed different anti-inflammatory effect in variety of animal models of anti-inflammatory.
• In Vitro:
  Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml.Dictamnine(Dic) induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. Inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway.
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• Animal Research:
  High performance centrifugal partition chromatography method was used for separation of the essential dictamnine,and anti-inflammatory effects of ethanol extracts and dictamnine were investigated by xylene-induced aruical swelling in mice and the abdominal capillary permeability in mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Fungal, inhibit, Dictamine, Dictamnine, Dectamine, Bacterial, Antiinfection, Anti-infection, Apoptosis

Compound Identifiers

PubChem CID

68085