Dicoumarol

SKU: orb1710681

Description

Dicoumarol is a natural hydroxycoumarin anticoagulant that acts as a competitive inhibitor of vitamin K epoxide reductase, disrupting vitamin K recycling. This inhibition depletes active vitamin K, preventing the synthesis of functional prothrombin and other clotting factors. It is widely used in coagulation research and in vivo models to study thrombosis and vitamin K-dependent processes.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 66-76-2
• MW: 336.3
• Purity: >99.99% (May vary between batches)
• Formula: C₁₉H₁₂O₆
• SMILES: Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
• Target: Dehydrogenase,PDK,Reductase,NADPH
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.97 mM);DMSO:3.37 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  PDK1:19.42 μM|NQO1:0.37 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dicoumarol, Dicumarol, Inhibitor, inhibit, NQO1, Pyruvate dehydrogenase kinase, PDK1, PDH, PDH kinase, PDHK

Compound Identifiers

PubChem CID

54676038