Diclofenac diethylamine

SKU: orb1310622

Description

Diclofenac Diethylamine is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a non-selective cyclooxygenase (COX) inhibitor. It is widely used in research to study inflammation and pain mechanisms in both in vitro biochemical assays and in vivo animal models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 78213-16-8
• MW: 369.29
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₂Cl₂N₂O₂
• SMILES: CCNCC.OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
• Target: COX,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.42 mM);DMSO:55 mg/mL (148.93 mM);Ethanol:69 mg/mL (186.85 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  COX-1 (ovine):5.1μM|COX-2 (human, CHO cells):1.3 nM|COX-1 (ovine):0.84 μM|COX-1 (human, CHO cells):4 nM
• In Vitro:
  The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, neural, ovine, NSCs, Diclofenac, Diclofenac diethylamine, Cyclooxygenase, COX-1, COX, COX-2, cells, CHO, Apoptosis, anti-inflammatory, cascade, caspase, stem

Compound Identifiers

PubChem CID

115087