Dichotomine C

SKU: orb3141859

Description

Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline alkaloid with anti-allergic properties. It inhibits the release of β-hexosaminidase from RBL-2H3 cells with an IC50 of 62 μM. Additionally, it suppresses antigen IgE-mediated release of TNF-α and IL-4 in RBL-2H3 cells, with IC50 values of 19 μM and 15 μM, respectively. This compound is applicable in the research of type I hypersensitivity reactions.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 755036-45-4
• MW: 286.28
• Formula: C₁₅H₁₄N₂O₄
• SMILES: [C@@H](CO)(O)C1=C2C(C=3C(N2)=CC=CC3)=CC(C(OC)=O)=N1
• Target: glycosidase,TNF,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

glycosidase,TNF,Interleukin