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Dichloromethotrexate

SKU: orb1702344

Description

Dichloromethotrexate is a dihydrofolate reductase (DHFR) inhibitor that blocks nucleotide synthesis, thereby suppressing DNA/RNA production. It is hepatically metabolized and excreted. This small molecule is used in biochemical research to study antifolate mechanisms, cell proliferation, and has been investigated in experimental oncology models.

Images & Validation

Key Properties

CAS Number528-74-5
MW523.33
FormulaC20H20Cl2N8O5
SMILESNC=1C2=C(N=CC(CN(C)C3=C(Cl)C=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3Cl)=N2)N=C(N)N1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information