Diallyl disulfide

SKU: orb1218433

Description

Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.

Key Properties

• CAS Number: 2179-57-9
• MW: 146.3
• Purity: >98% (HPLC)
• Formula: C₆H₁₀S₂
• SMILES: C=CCSSCC=C
• Target: IL Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (683.67 mM)

Bioactivity

• In Vivo:
  Animal model: Male C57BL6/J mice (6-8 weeks). Dosage: 40, 80 mg/kg. Administration: IP; pre-treatment 1 h before a single LPS injection (100 μg/kg). Result: Prevented LPS-induced increases in immobility time in the TST and FST in mice.
• In Vitro:
  Cell Viability Assay Cell line: HT-29 cells. Concentration: 30, 60, 120 and 240 μM. Incubation time: 12, 24, 48 h. Result: Suppressed HT-29 cell growth by 5.3, 23.1, 45.6 and 68.3% with 30, 60, 120 and 240 μM for 24 h, respectively. Cell Cycle Analysis Cell line: HT-29 cells. Concentration: 30, 60, 120 μM. Incubation time: 24 h. Result: The percentage of cells in the G2/M-phase was found to be 23.6, 25.9, 39.7 and 61.0% with 30, 60, 120 and 240 μM, respectively. RT-PCR Cell line: HT-29 cells. Concentration: 120 μM. Incubation time: Result: The mRNA levels of ARPC3, SPINT2, SOD1, p21 and TACSTD2 were 3.52-, 7.98-, 15.6-, 13.47- and 5.92-fold higher than those in the primary cultured cells, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IL Receptor