Diacerein

SKU: orb1226420

Description

Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13739-02-1
• MW: 368.29
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₂O₈
• SMILES: O=C(C(C=C1C2=O)=CC(OC(C)=O)=C1C(C3=C2C=CC=C3OC(C)=O)=O)O
• Target: IL Receptor
• Solubility: DMSO: 48 mg/mL (130.33 mM)

Bioactivity

• In Vivo:
  Animal model: Male BALB/c mice at 6-8 weeks of age. Dosage: 50, 100, 200 mg/kg. Administration: Gavaged; daily; a week. Result: Reduced systematic inflammation and mucus secretion In vivo. Exhibited anti-inflammatory property to significantly reduce inflammation and repair damaged airway.
• In Vitro:
  Cell Viability Assay Cell line: Cal-78 and SW-1353 cells. Concentration: 30, 100, and 300 μM. Incubation time: 24, 48 h. Result: Inhibited cell growth in a concentration dependent manner in both cell lines. Cell Cycle Analysis Cell line: Cal-78 and SW-1353 cells. Concentration: 30, 100, and 300 μM. Incubation time: 48 h. Result: Caused a pronounced decrease in the number of cells in the G1 phase, accompanied by a significant increase of the number of S and G2/M phase cells, indicating a G2/M arrest in SW-1353 cells. Western blot analysis. Cell line: Cal-78 and SW-1353 cells. Concentration: 30, 100, and 300 μM. Incubation time: 24 h. Result: Induced a small, but not significant change, for the expression of CDK1, whereas the cyclin B1 and CDK2 levels were significantly down-regulated in the case of Cal-78 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DAR | 4,5-Diacetylrhein | SF 277

Quick Database Links

Gene Symbol

IL Receptor