DHW-221

SKU: orb3173458

Description

DHW-221 is an orally active dual PI3K/mTOR inhibitor demonstrating potent inhibition at nanomolar levels across all four Class I PI3K isoforms and mTOR (PI3Kα, IC50= 0.50 nM; PI3Kβ, IC50= 1.9 nM; PI3Kγ, IC50= 1.8 nM; PI3Kδ, IC50= 0.74 nM; mTOR, IC50= 3.9 nM). By blocking the PI3K/Akt/mTOR pathway, DHW-221 induces mitochondrial apoptosis and paraptosis (through endoplasmic reticulum stress and MAPK signaling) and causes cell cycle arrest, thereby inhibiting cell migration, invasion, and angiogenesis to exert its antitumor effects. It suppresses tumor growth in A549/Taxol and HCC827 mouse models and is applicable in research related to non-small cell lung cancer (NSCLC), colon cancer, and breast cancer.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2378831-21-9
• MW: 552.55
• Formula: C₂₇H₂₂F₂N₄O₅S
• SMILES: O=S(=O)(NC=1C=C(C=NC1OC)C=2C=CC=3N=CN(C4=CC=C(OCCO)C=C4)C3C2)C5=CC=C(F)C=C5F
• Target: CDK,Mitochondrial Metabolism,HIF/HIF Prolyl-Hydroxylase,Akt,p38 MAPK,VEGFR,mTOR,PI3K,Apoptosis,P-gp,MMP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Mitochondrial Metabolism,HIF/HIF Prolyl-Hydroxylase,Akt,p38 MAPK,VEGFR,mTOR,PI3K,Apoptosis,P-gp,MMP