DHW-208

SKU: orb3173691

Description

PI3K-IN-4 is a potent pan-PI3K inhibitor demonstrating high activity across three PI3K isoforms with picomolar IC50 values. It exhibits excellent inhibitory activity against PI3Kα (IC50 = 0.20 nM), PI3Kβ (IC50 = 2.99 nM), PI3Kδ (IC50 = 0.48 nM), and PI3Kγ (IC50 = 0.58 nM), but shows no significant activity against EGFR. By interfering with the PI3K/Akt signaling pathway, PI3K-IN-4 hinders cancer cell proliferation, blocks colony formation, and induces apoptosis (apoptosis). This compound is applicable in research related to lung cancer, colon cancer, and breast cancer.

Key Properties

• CAS Number: 2269470-35-9
• MW: 553.54
• Formula: C₂₅H₂₁F₂N₇O₄S
• SMILES: O=S(=O)(NC=1C=C(C=NC1OC)C2=CC=C3N=CN=C(NC=4C=NN(C4)CCO)C3=C2)C5=CC=C(F)C=C5F
• Target: Apoptosis,Akt,PI3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Akt,PI3K