DHTP

SKU: orb3210483

Description

DHTP is a selective allosteric inhibitor that suppresses the ATPase activity and microtubule depolymerization activity of kinesin-13. It exhibits inhibitory effects on Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, while not affecting other kinesin family members. DHTP modulates intracellular microtubule dynamics, resulting in reduced microtubule dynamism. This compound connects the overexpression of kinesin-13 with cancer and Paclitaxel resistance, making it a valuable tool for cancer research.

Key Properties

• CAS Number: 1620225-37-7
• MW: 512.96
• Formula: C₂₅H₂₁ClN₂O₆S
• SMILES: C(OC(C)C)(=O)C=1C(N2C(S/C(=C\C3=CC=C(OCC(O)=O)C=C3)/C2=O)=NC1)C4=CC=C(Cl)C=C4
• Target: Kinesin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Kinesin