DHODH-IN-33

SKU: orb3174140

Description

DHODH-IN-33 is a selective DHODH inhibitor that exhibits potent activity against A549 cells (IC50 = 5.22 μM) and 5637 cells (IC50 = 3.03 μM). It induces autophagy-dependent ferroptosis, characterized by mitochondrial dysfunction, lipid peroxidation, and accumulation of ROS, without significant toxicity in vivo. The anticancer effect of DHODH-IN-33 is achieved through promoting autophagy-dependent degradation of dihydroorotate dehydrogenase. This compound can be used in studies related to non-small cell lung cancer and bladder cancer.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3026839-88-0
• MW: 407.48
• Formula: C₂₃H₂₁NO₄S
• SMILES: O=S(=O)(C1=CC=C(C=C1)C)N2C3=CC=C(OC)C=C3CC4OC=5C=CC=CC5C24
• Target: Ferroptosis,Autophagy,ROS Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis,Autophagy,ROS Kinase