DHODH-IN-15

SKU: orb1709880

Description

DHODH-IN-15 is a hydroxyfuran analog of A771726 and functions as a dihydroorotate dehydrogenase (DHODH) inhibitor, exhibiting an IC50 of 11 μM against rat liver DHODH. This compound is utilized in rheumatoid arthritis research, supporting investigations into immunomodulation and cellular proliferation in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1364791-88-7
• MW: 281.27
• Purity: 97.26% (May vary between batches)
• Formula: C₁₅H₁₁N₃O₃
• SMILES: N(C(=O)C=1C(=O)NON1)C2=CC=C(C=C2)C3=CC=CC=C3
• Target: Dehydrogenase,DNA/RNA Synthesis
• Solubility: DMSO:55 mg/mL (195.54 mM)

Bioactivity

• Target IC50:
  DHODH (rat liver):11 μM
• In Vitro:
  DHODH-IN-15 is a hydroxyfuran analogue of A771726, in which the biphenyl skeleton does not carry any substituents. Turning to the derivative DHODH-IN-15, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, DHODH-IN-15 was found to bind in a BQN-like manner, ie, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. On 1D3G and 1UUO, in any case, no interaction of Tyr356 with Leflunomide was found, but when 2BXV was used as a docking target, a large part of this posture was found.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat liver DHODH, DHODH IN 15, DHODH, DHODHIN15, DHODH-IN-15

Compound Identifiers

PubChem CID

57381309