DHODH-IN-12

SKU: orb1709883

Description

DHODH-IN-12 is a leflunomide-based compound functioning as a dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07. This small molecule is utilized in biochemical research to study DHODH's role in pyrimidine synthesis, applicable in both cellular and enzymatic assays investigating related pathways.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1263303-93-0
• MW: 203.2
• Purity: 99.53% (May vary between batches)
• Formula: C₁₀H₉N₃O₂
• SMILES: N(C(/C(/C#N)=N/O)=O)C1=CC=C(C)C=C1
• Target: DNA/RNA Synthesis,Dehydrogenase
• Solubility: DMSO:60 mg/mL (295.28 mM)

Bioactivity

• In Vitro:
  A compound structurally related to leflunomide was designed, which contained a furan ring. Compound 12a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanoxime DHODH-IN-12. DHODH-IN-12 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the poor stereochemistry of the oxime substructure.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODH, DHODH IN 12, DHODHIN12, DHODH-IN-12

Compound Identifiers

PubChem CID

6911709