DHODH-IN-11

SKU: orb1309766

Description

DHODH-IN-11 is a leflunomide-based derivative and a weak inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting a pKa of 5.03. This small molecule is utilized in biochemical research to study DHODH's role in pyrimidine biosynthesis, with applications in investigating related pathways in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1263303-95-2
• MW: 265.27
• Purity: 98.14% (May vary between batches)
• Formula: C₁₅H₁₁N₃O₂
• SMILES: O\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
• Target: Dehydrogenase,DNA/RNA Synthesis
• Solubility: DMSO:25 mg/mL (94.24 mM)

Bioactivity

• Target IC50:
  DHODH:5.03(pKa)
• In Vitro:
  A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiinflammatory, DHODH, DHODH IN 11, DHODHIN11, DHODH-IN-11, Dihydroorotate Dehydrogenase, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, cyano-oximes, Leflunomide, inhibit, Inhibitor, RNASynthesis, RNA Synthesis, Rat

Compound Identifiers

PubChem CID

51031365