DHBP dibromide

SKU: orb1220434

Description

DHBP dibromide is calcium release and a muscle relaxant inhibitor.

Key Properties

• CAS Number: 6159-05-3
• MW: 514.38
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₈Br₂N₂
• SMILES: [Br-].[Br-].CCCCCCC[n+]1ccc(cc1)-c1cc[n+](CCCCCCC)cc1
• Target: Calcium Channel
• Solubility: DMSO:30 mg/mL (58.32 mM)

Bioactivity

• In Vitro:
  DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO

Quick Database Links

Gene Symbol

Calcium Channel