DGY-09-192

SKU: orb3175239

Description

DGY-09-192 is a PROTAC FGFR1/2 degrader with DC50 values of 4.35 nM for FGFR1 and 70 nM for FGFR2. It selectively degrades wild-type FGFR1/2 and various FGFR2 fusion proteins, including FGFR2-PHGDH and FGFR2-OPTN. In both in vitro and in vivo studies, DGY-09-192 inhibits downstream FGFR signaling pathways by reducing the phosphorylation of FRS2Y196 and ERK1/2T202/Y204.

Key Properties

• CAS Number: 2504949-52-2
• MW: 1017.04
• Formula: C₄₉H₅₉Cl₂N₁₁O₇S
• SMILES: C([C@@H](NC(CN1CCN(CC1)C2=CC=C(NC=3C=C(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C)N=CN3)C=C2)=O)[C@@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5
• Target: FGFR,PROTACs,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

FGFR,PROTACs,ERK