DFP00173

SKU: orb1309768

Description

DFP00173 is a potent and selective small-molecule inhibitor of aquaporin 3 (AQP3), exhibiting IC50 values of approximately 0.1-0.4 µM against both mouse and human isoforms with selectivity over AQP7 and AQP9. This tool compound is used in research to investigate AQP3's role in cell proliferation, migration, and skin hydration in various in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 672286-03-2
• MW: 332.16
• Purity: 99.55% (May vary between batches)
• Formula: C₁₁H₇Cl₂N₃O₃S
• SMILES: [O-][N+](=O)c1cc(NC(=O)Nc2c(Cl)cccc2Cl)cs1
• Target: Aquaporin
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM);DMSO:45 mg/mL (135.48 mM)

Bioactivity

• Target IC50:
  AQP3:0.1-0.4 μM
• In Vitro:
  DFP00173 inhibits the glycerol permeability of human red blood cells with an IC50 of approximately 0.2 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DFP 00173, DFP00173, DFP-00173, AQP, AQP3, inhibit, Inhibitor, isoforms, homologous, glycerol, human, erythrocytes, permeability, selective

Compound Identifiers

PubChem CID

2806296