DF-003

SKU: orb3173462

Description

DF-003 is a selective, orally active, ATP-competitive ALPK1 inhibitor capable of crossing the blood-brain barrier. It effectively inhibits human ALPK1 and ALPK1[T237M] with IC50 values of 1.5 nM and 16 nM, respectively. The compound exhibits selectivity over the nearest kinase by more than 860-fold. DF-003 suppresses the upregulation of TNF, CXCL10, or CXCL8 in HEK-293 cells. It has applications in the study of retinopathy, optic nerve edema, splenomegaly, anhidrosis, and headaches associated with ROSAH syndrome.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2765462-07-3
• MW: 486.97
• Formula: C₂₄H₂₁ClF₂N₄OS
• SMILES: [C@](C#C)(C)(C=1N=C(NC(=O)C2=C(F)C=C(C=C2F)N3CCNCC3)SC1)C4=CC=C(Cl)C=C4
• Target: CXCR,Serine/threonin kinase,TNF,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CXCR,Serine/threonin kinase,TNF,Interleukin