Dextran sulfate sodium salt (MW 5000)

SKU: orb1308837

Description

Dextran sulfate sodium salt (MW 4500-5500)

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 9011-18-1
• MW: 9000-20000
• Formula: (C₆H₇Na₃O₁₄S₃)n
• Target: Apoptosis,Complement System,HIV Protease
• Solubility: H2O:100 mg/mL;DMSO:Insoluble

Bioactivity

• Target IC50:
  HIV-1:9.1 µg/mL
• In Vivo:
  METHODS: To investigate the effect of Dextran sulfate sodium salt (MW 4500-5500) on endothelial injury after ischemia and reperfusion in a rat model of inferior renal aortic clamp, Dextran sulfate sodium salt (MW 4500-5500)(5 mg/mL, 200 μL) was immediately locally infused into the ischemic aortic segment of rats before reperfusion. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) inhibits complement activation and reduces endothelial injury after ischemia and reperfusion in the rat model of inferior renal aortic clamp.
• In Vitro:
  METHODS: MT-4 cells were treated with Dextran sulfate sodium salt (MW 4500-5500) (25 μg/mL) for 24 hours. The inhibitory effect on HIV-1 replication was observed, and the effects of the drug on cytotoxicity and reverse transcriptase activity were evaluated. RESULTS: Dextran sulfate sodium salt (MW 4500-5500) has a significant selective inhibitory effect on HIV-1, with an IC50 value of 2.3-8.8 µg/ml, and does not show toxicity to host cells at high concentrations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dextran sulfate sodium, Dextran sulfate sodium salt (MW 4500 5500), Dextran sulfate sodium salt (MW 45005500), Dextran sulfate sodium salt (MW 5000), DSS, Apoptosis, HIV, HIV Protease, HIVProtease

Quick Database Links

Gene Symbol

Apoptosis,Complement System,HIV Protease

HS Raoof, SMA Hassan, SH Ibrahim Role of Quercus Infectoria Galls Extract in Colitis-Induced Colorectal Cancer by AOM-DSS in Albino Rats pvj.com.pk, (2025)

PubMed: