Dexmedetomidine hydrochloride

SKU: orb1226247

Description

An agonist of α2-adrenergic receptor that used in veterinary medicine for its analgesic and sedative properties; also protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy in rats.(In Vitro):Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine.Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0.(In Vivo):Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145108-58-3
• MW: 236.7405
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₇ClN₂
• SMILES: CC1=C(C)C([C@H](C)C2=CN=CN2)=CC=C1.Cl
• Target: Adrenergic Receptor
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Medetomidine (10-100 μg/kg; i. v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats. Animal model: Female Sprague-Dawley rats (270-350 g). Dosage: 1, 5, 10, 50, 100 mg/kg. Administration: I. v. at 5-min intervals. Result: Produced the pupil dilatation of 2.5 mm (approximately half of the maximum effect) at the cumulative dose of 4 μg/kg.
• In Vitro:
  Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine. Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Adrenergic Receptor