Dexamethasone (DHAP)

SKU: orb1224934

Description

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects(In Vitro):MK-3207 (0.3, 0.6, 1.1, 2.3, 4.5, 9.0 nM; 30 min) potently blocks human α-CGRP-stimulated cAMP responses in human CGRP receptor-expressing HEK293 cells.(In Vivo):MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 μg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81%.MK-3207 (10 mg/kg; p.o.; single) shows the CSF/plasma ratio is 2 to 3%.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-02-2
• MW: 392.46
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₉FO₅
• SMILES: O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])CCC2=C1
• Target: Annexin A
• Solubility: Ethanol: 6 mg/mL (15.28 mM); DMSO: 79 mg/mL (201.29 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHAP

Quick Database Links

Gene Symbol

Annexin A