Desmethylglycitein

SKU: orb1297483

Description

Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) is a novel PKCα inhibitor that suppresses solar UV-induced MMP-1 expression. This small molecule exhibits antioxidant and potential anti-cancer properties, making it a useful research tool for studying skin photoaging, oncology, and signal transduction in both in vitro and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 17817-31-1
• MW: 270.24
• Purity: 98.93% (May vary between batches)
• Formula: C₁₅H₁₀O₅
• SMILES: Oc1ccc(cc1)-c1coc2cc(O)c(O)cc2c1=O
• Target: PKC,CDK,PI3K
• Solubility: DMSO:247.5 mg/mL (915.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.8 mM)

Bioactivity

• In Vivo:
  A single administration of Desmethylglycitein significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.Moreover, treatment with Desmethylglycitein alone enhanced learning and memory performance in the same behavioral tests. Desmethylglycitein improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice
  Read more...
• In Vitro:
  Molecular studies showed that Desmethylglycitein significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that Desmethylglycitein significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Cyclin dependent kinase, Desmethylglycitein, CDK2, CDK1, CDK, 6,7,4'-Trihydroxyisoflavone, 4',6,7-Trihydroxyisoflavone, Phosphoinositide 3-kinase, Protein kinase C, PI3K, PKC, PKCα

Compound Identifiers

PubChem CID

5284649