Desmethylanethol trithione

SKU: orb1223220

Description

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.

Key Properties

• CAS Number: 18274-81-2
• MW: 226.33
• Purity: >98% (HPLC)
• Formula: C₉H₆OS₃
• SMILES: c1cc(O)ccc1c1cc(=S)ss1
• Target: S6 Kinase
• Solubility: In Vitro: DMSO : 125 mg/mL (552.27 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADT-OH | Desmethylanethol trithione | ACS1

Quick Database Links

Gene Symbol

S6 Kinase