Desmethyl Erlotinib

SKU: orb1300865

Description

Desmethyl Erlotinib (CP-473420) is the primary active metabolite of the EGFR inhibitor Erlotinib. It exhibits potent inhibitory activity against EGFR with an IC50 of 2 nM, making it a valuable reference compound for studying drug metabolism and efficacy in cancer research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 183321-86-0
• MW: 379.41
• Purity: 98.62% (May vary between batches)
• Formula: C₂₁H₂₁N₃O₄
• SMILES: COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO
• Target: Drug Metabolite,EGFR
• Solubility: DMSO:83 mg/mL (218.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.7 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  EGFR:2 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Desmethyl Erlotinib, DrugMetabolite, Drug Metabolite, CP 473420, CP 373420, CP473420, CP-473420, CP373420, CP-373420, EGFR, inhibit, Inhibitor, O-Desmethyl Erlotinib, OSI 420, OSI420, OSI-420

Compound Identifiers

PubChem CID

10317566