Desipramine hydrochloride

SKU: orb1310096

Description

Desipramine hydrochloride is a secondary amine tricyclic antidepressant that acts by inhibiting the reuptake of norepinephrine and serotonin, thereby increasing their synaptic availability. It is widely used in neuroscience research to study monoamine transporters, depression models, and neuropharmacology in both in vitro and in vivo experimental systems.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58-28-6
• MW: 302.84
• Purity: 99.96% (May vary between batches)
• Formula: C₁₈H₂₃ClN₂
• SMILES: Cl.CNCCCN1c2ccccc2CCc2ccccc12
• Target: 5-HT Receptor,Adrenergic Receptor,Serotonin Transporter,Dopamine Receptor
• Solubility: DMSO:252 mg/mL (832.12 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (10.9 mM)

Bioactivity

• Target IC50:
  NET:4 nM (Ki)|DAT:78720 nM (Ki)|SERT:61 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DAT, Dopamine Receptor, DopamineReceptor, Dopamine Transporter, Desmethylimipramine, Desipramine, Desipramine hydrochloride, Desipramine Hydrochloride, AdrenergicReceptor, Adrenergic Receptor, 5HT Receptor, 5HTReceptor, 5-HT, 5-HTT, G35020, G-35020, EX 4355, EX4355, EX-4355, G 35020, Inhibitor, inhibit, JB 8181, JB8181, JB-8181, Norimipramine, NSC 114901, NSC114901, NSC-114901, SLC6A4, SLC6A3, SERT, Serotonin Transporter, SerotoninTransporter

Compound Identifiers

PubChem CID

65327