Desethyl chloroquine diphosphate

SKU: orb1709894

Description

Desethyl chloroquine diphosphate

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 247912-76-1
• MW: 487.81
• Purity: 99.72%
• Formula: C₁₆H₂₈ClN₃O₈P₂
• SMILES: O=P(O)(O)O.ClC1=CC2=NC=CC(NC(CCCNCC)C)=C2C=C1.O=P(O)(O)O
• Target: TLR,Autophagy,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.05 mM);DMSO:1 mg/mL (2.05 mM);H2O:10 mg/mL (20.5 mM)

Bioactivity

• In Vivo:
  In the study, amochloroquine was administered by intraperitoneal injection to wild-type mice and Huntington's chorea mice. Levels of amochloroquine and its metabolites were compared in blood, brain and muscle tissue using LC-MS/MS (liquid chromatography-mass spectrometry) techniques. Despite the low concentrations of amochloroquine (5-15 μM), amochloroquine was more stable in the brain than in blood and muscle from 4 to 24 hours after administration. At the same time, Desethyl chloroquine (the active metabolite of amochloroquine) concentrations in blood and muscle decreased after 24 hours, while concentrations in the brain were lower and increased slightly during this period. Desethyl chloroquine diphosphate is a salt form of Desethyl chloroquine.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Desethyl chloroquine

Compound Identifiers

PubChem CID

49849615