Deschloroclozapine

SKU: orb1309748

Description

Deschloroclozapine, a Clozapine metabolite, is a potent and selective agonist for chemogenetic DREADDs (hM3Dq & hM4Di), with binding affinities (Ki) of 6.3 and 4.2 nM respectively. It is a key research tool for precise neuronal modulation in vivo and in vitro for neuroscience and behavioral studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 1977-07-7
• MW: 292.38
• Purity: 99.98%
• Formula: C₁₈H₂₀N₄
• SMILES: CN1CCN(CC1)C1=Nc2ccccc2Nc2ccccc12
• Target: Serotonin Transporter,AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.68 mM);DMSO:127.5 mg/mL (436.08 mM)

Bioactivity

• Target IC50:
  M4Di (human):4.2 nM(Ki)|M3Dq (human):6.3 nM(Ki)

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamne D1, Dopamne D2, Dopamne D4, DREADDs, Deschloroclozapine, Muscarinic acetylcholine receptor, muscarinic-based, inhibit, Inhibitor, mAChR, hM3Dq, hM4Di, Serotonin S2A, Serotonin S2C, Serotonin S3, Serotonin Transporter, SerotoninTransporter, serotonin

Compound Identifiers

PubChem CID

16103