Desacetylcinobufotalin

SKU: orb1684651

Description

Desacetylcinobufotalin is a natural compound that triggers apoptosis in HepG2 cells through modulation of Bax and Bcl-2 protein levels. It serves as a valuable research tool for investigating apoptosis mechanisms and has demonstrated activity in both in vitro cell-based assays and in vivo models of liver cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 4099-30-3
• MW: 416.51
• Purity: 99.88% (May vary between batches)
• Formula: C₂₄H₃₂O₆
• SMILES: C[C@]12[C@]3([C@](O3)([C@H](O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](O)(CC5)C[C@@H](O)CC6)[H])[H]
• Target: Apoptosis,Bcl-2 Family
• Solubility: DMSO:80 mg/mL (192.07 mM)

Bioactivity

• In Vitro:
  Desacetylcinobufotalin displayed a marked inhibitory effect on HepG2 cells, and the IC50 value is 0.0279μmol/ml. The expression of Bax was significantly increased, and the expression of Bcl-2 was markedly decreased, compared to the control.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Desacetylcinobufotalin, Deacetylcinobufotalin

Compound Identifiers

PubChem CID

15513544