Dermorphin

SKU: orb1220397

Description

Dermorphin is agonist of μ-opioid receptor (MOR) agonist.

Key Properties

• CAS Number: 77614-16-5
• MW: 802.87
• Purity: >98% (HPLC)
• Formula: C₄₀H₅₀N₈O₁₀
• SMILES: CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CO)C(N)=O
• Target: Opioid Receptor
• Solubility: In Vitro: H2O : 120 mg/mL (149.46 mM)

Bioactivity

• In Vitro:
  Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Opioid Receptor