Derenofylline

SKU: orb1299047

Description

Derenofylline is a potent and selective adenosine A1 receptor antagonist, exhibiting a Ki value of 1 nM in vitro. It is a valuable research tool for investigating adenosine signaling in fields such as renal physiology, cardiac ischemia, and central nervous system disorders, with utility in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 251945-92-3
• MW: 308.38
• Purity: 99.84% (May vary between batches)
• Formula: C₁₈H₂₀N₄O
• SMILES: O[C@H]1CC[C@@H](CC1)Nc1nc(nc2[nH]ccc12)-c1ccccc1
• Target: Adenosine Receptor
• Solubility: DMSO:22.5 mg/mL (72.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.21 mM)

Bioactivity

• Target IC50:
  A3 receptor:200 nM (Ki)|A1 receptor:1 nM(Ki)|A2A receptor:398 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cardiomyopathy, Derenofylline, AdenosineReceptor, Adenosine Receptor, A1, fibrosis, Inhibitor, inhibit, Nephrectomy, P1 receptor, SLV 320, SLV320, SLV-320, uraemic

Compound Identifiers

PubChem CID

9953065