Deoxyelephantopin

SKU: orb1297566

Description

Deoxyelephantopin is a bioactive sesquiterpene lactone with demonstrated antitumor, anti-inflammatory, hepatoprotective, and wound-healing properties. Its mechanisms involve the inhibition of key signaling pathways, including NF-κB, MAPK, PI3K/Akt, and β-catenin, as evidenced in various in vitro and in vivo research models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 29307-03-7
• MW: 344.36
• Purity: 99.71% (May vary between batches)
• Formula: C₁₉H₂₀O₆
• SMILES: [H][C@@]12C\C(C)=C/[C@@]3([H])OC(=O)C(=C)[C@]3([H])[C@H](CC(=C1)C(=O)O2)OC(=O)C(C)=C
• Target: NF-κB
• Solubility: DMSO:100 mg/mL (290.39 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.58 mM)

Bioactivity

• In Vitro:
  Deoxyelephantopin was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4, and protein expression and resultant enzymatic activity. The mRNA and protein expression of cytochrome isoforms were carried out using an optimized multiplex qRT-PCR assay and Western blot analysis, respectively. Human CYP3A4 protein expression was determined using an optimized hCYP3A4-HepG2 cell-based assay and the enzymatic activity was evaluated using P450-Glo CYP3A4 assay. The molecular interaction and possible inhibition of Deoxyelephantopin of the CYP3A4 enzyme was determined in silico and further validated using substrate-specific CYP3A4 inhibition assays. Deoxyelephantopin produced no significant effect on the CYP1A2 and CYP2D6 mRNA and protein expression. However, it has a weak induction effect on CYP3A4 at the transcriptional level

Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-catenin, PI3K, ROS, Caspase, Bcl-2, anticancer, Akt, Deoxyelephantopin, MAPK, inhibit, Inhibitor, NF-kB, NF-κB, NFκB, NFkB, Nuclear factor-kappaB, Nuclear factor-κB

Compound Identifiers

PubChem CID

5281438