Deoxycorticosterone acetate

SKU: orb1224647

Description

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Key Properties

• CAS Number: 56-47-3
• MW: 372.5
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₂O₄
• SMILES: CC(OCC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O)=O
• Target: Others
• Solubility: Ethanol: 6 mg/mL (16.1 mM); DMSO: 11 mg/mL (29.53 mM)

Bioactivity

• In Vivo:
  Animal model: MR (mineralocorticoid receptor) mutant mice (MRCdh5Cre) and MR wild-type mice (MRwild-type) treated with unilateral nephrectomy (12-week-old). Dosage: 2.5 mg/d. Administration: Subcutaneous implantation; 42 days; treated with 2 mg Tamoxifen (HY-13757A) (20 mg/mL in sunflower oil and 10% ethanol; i.p.; once daily on 5 consecutive days) at least 4 weeks before nephrectomy. Result: Increased the blood pressure without differences between both genotypes (MRCdh5Cre and MRwild-type). Resulted glomerular injury and proteinuria, renal inflammation and fibrosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deoxycorticosterone Acetate | DOCA | Percotol | Cortexone acetate |

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