Demethylwedelolactone

SKU: orb1301328

Description

Demethylwedelolactone, a natural compound from Eclipta alba, is a trypsin inhibitor (IC50 = 3.0 µM). It demonstrates anti-invasive properties against breast cancer cells in vitro, making it a candidate for oncology research focused on metastasis.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 6468-55-9
• MW: 300.22
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₈O₇
• SMILES: Oc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1
• Target: Serine Protease
• Solubility: DMSO:22.5 mg/mL (74.95 mM)

Bioactivity

• Target IC50:
  Trypsin:3.0 μM
• In Vitro:
  demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice. DWEL derivatives exert anti-invasive growth effect on breast cancer cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SerineProtease, Threonine proteases, Serine endopeptidases, Ser/Thr Protease, Serine Protease, Serine proteases, trypsin, Demethylwedelolactone, Inhibitor, inhibit, NF-κB, MMP, ERK, MEK, IkB, IKK

Compound Identifiers

PubChem CID

5489605