Demethylisoencecalin

SKU: orb1296960

Description

Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) is a natural product exhibiting anti-hyperglycemic properties. It is a research compound used in metabolic disorder studies, with investigations into its mechanisms conducted in both in vitro assays and in vivo models of diabetes.

Research Area

Metabolism Research

Key Properties

• CAS Number: 24672-84-2
• MW: 218.25
• Purity: 99.89% (May vary between batches)
• Formula: C₁₃H₁₄O₃
• SMILES: OC1=C2C(OC(C)(C)C=C2)=CC=C1C(C)=O
• Target: Glucosidase,glycosidase,Others
• Solubility: DMSO:60 mg/mL (274.91 mM)

Bioactivity

• In Vitro:
  Demethylisoencecalin (1) and caleins A (4) and C (5) (3.16–31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during an oral sucrose tolerance test (OSTT, 3 g/kg) in normal and nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those of acarbose (5 mg/kg). During the isolation of 1, 4, and 5, four additional metabolites not previously reported for the plant, were obtained, namely 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3), herniarin (6), scoparone (7), and 4′,7-dimethylapigenin (8). In addition, the structure of calein C (5) was confirmed by X-ray analysis. Pharmacological evaluation of the essential oil of the species (31.6–316.2 mg/kg, p.o.) provoked also an important decrement of blood glucose levels during an OSTT.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran, Demethylisoencecalin

Compound Identifiers

PubChem CID

827487