Demethoxycurcumin

SKU: orb1300195

Description

Demethoxycurcumin is a bioactive curcuminoid with demonstrated antioxidant, anti-inflammatory, and anti-proliferative properties. It exhibits anti-acanthamoebic effects and shows potential as a combination therapy in drug-resistant cancers, notably by activating AMPK to inhibit metabolic and oncogenic pathways in triple-negative breast cancer cells in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 22608-11-3
• MW: 338.35
• Purity: 99.86%
• Formula: C₂₀H₁₈O₅
• SMILES: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)ccc1O
• Target: Apoptosis,Autophagy,Antibacterial,NO Synthase,Antioxidant,Cholinesterase (ChE)
• Solubility: DMSO:112.5 mg/mL (332.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.39 mM)

Bioactivity

• Target IC50:
  BACE1:17 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Demethoxycurcumin, Desmethoxycurcumin, Curcumin II, Autophagy, Bacterial, Apoptosis, Antioxidant, Monodemethoxycurcumin

Compound Identifiers

PubChem CID

5469424