Dehydropachymic acid

SKU: orb1297399

Description

(S)-Leucic acid, a metabolite of the branched-chain amino acid leucine, is utilized in research exploring muscle metabolism. Studies investigate its potential roles in protein synthesis and muscle mass regulation, both in cellular (in vitro) and animal (in vivo) models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 77012-31-8
• MW: 526.75
• Purity: 99.78%
• Formula: C₃₃H₅₀O₅
• SMILES: [H][C@]1([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@@]2(C)C3=CC[C@@]4([H])C(C)(C)[C@H](CC[C@]4(C)C3=CC[C@]12C)OC(C)=O
• Target: Immunology/Inflammation related,Autophagy
• Solubility: DMSO:5.27 mg/mL (10 mM)

Bioactivity

• In Vitro:
  Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), Dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Immunology related, Immunologyrelated, Immunology/Inflammation related, Inflammationrelated, Inflammation related, Inhibitor, Dehydropachymic acid, Autophagy

Compound Identifiers

PubChem CID

15226717