Dehydroeffusol

SKU: orb1297400

Description

Dehydroeffusol is a bioactive small molecule with demonstrated anti-cancer, anxiolytic, and sedative properties. Research applications include in vitro studies showing it inhibits gastric cancer cell growth and tumorigenicity by selectively inducing endoplasmic reticulum stress and apoptosis.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 137319-34-7
• MW: 250.29
• Purity: 99.35%
• Formula: C₁₇H₁₄O₂
• SMILES: Cc1c(O)ccc2c1ccc1cc(O)cc(C=C)c21
• Target: MMP,ERK,Apoptosis,GPCR

Bioactivity

• In Vitro:
  Dehydroeffusol selectively activated the intracellular tumor suppressive stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (DDIT3), through upregulation of activating transcription factor 4 (ATF4). Concurrently, Dehydroeffusol suppressed the expression of the cell survival and ER stress marker glucose regulated protein of molecular mass 78 (GRP78) via downregulation of the transcription factor ATF6. In addition, Dehydroeffusolmarkedly activated the stress response signaling pathway MEKK4-MKK3/6-p38-DDIT3, but significantly inhibited ERK signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-Ethenyl-1-Methylphenanthrene-2,7-Diol, Apoptosis, Antifection, ATF4, ATF6, Dehydro Effusol, Dehydroeffusol, MMP, inhibit, Inhibitor, ERK, GRP78

Compound Identifiers

PubChem CID

5316810