Dehydrocorydaline chloride

SKU: orb1309778

Description

Dehydrocorydaline chloride

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 10605-03-5
• MW: 401.88
• Purity: 99.88%
• Formula: C₂₂H₂₄ClNO₄
• SMILES: [Cl-].COc1ccc2c(C)c3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC
• Target: Caspase,Autophagy,Parasite,p38 MAPK,PARP,Bcl-2 Family
• Solubility: DMSO:24 mg/mL (59.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM)

Bioactivity

• In Vivo:
  Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice.
• In Vitro:
  Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression of muscle-specific proteins (including MyoD, myogenin, and myosin heavy chain), and enhanced p38 MAPK activation and the interaction between MyoD and E protein. Additionally, dehydrohydroxyproline restored defects in differentiation-induced p38 MAPK activation and differentiation of myoblasts caused by Cdo. Dehydrohydroxyproline significantly inhibited MCF-7 cell proliferation in a dose-dependent manner, reversible by the caspase-8 inhibitor Z-IETD-FMK. It also increased DNA fragmentation without affecting ΔΨm, elevated Bax protein levels, decreased Bcl-2 protein levels, and induced caspase-7 and -8 activation and PARP cleavage, without affecting caspase-9. These findings suggest that dehydrohydroxyproline inhibits MCF-7 cell proliferation by inducing apoptosis through Bax/Bcl-2 regulation, caspase activation, and PARP cleavage.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p38 MAPK, poly ADP ribose polymerase, p38MAPK, Parasite, PARP, inhibit, Inhibitor, Dehydrocorydaline, Dehydrocorydaline chloride, Dehydrocorydaline Chloride, Caspase, caspase-7, caspase-8, Autophagy, Bcl-2, Bcl-2 Family, Bax, 13-Methylpalmatine, 13-Methylpalmatine Chloride, 13-Methylpalmatine chloride

Compound Identifiers

PubChem CID

160950