(±)-Dehydroaltenusin

SKU: orb3141960

Description

(±)-Dehydroaltenusin is an antibiotic that serves as a selective inhibitor of eukaryotic DNA polymerase α (pol α), exhibiting an IC50 of 0.68 μM. It can be isolated from the fungus Alternaria tenuis. The compound competitively inhibits the activity of DNA template primers (Ki: 0.23 μM) and non-competitively inhibits the activity of 2'-deoxyribonucleoside 5'-triphosphate substrates (Ki: 0.18 μM). Additionally, (±)-Dehydroaltenusin can induce S-phase cell cycle arrest and apoptosis in cancer cells and is applicable in research on cancers such as human adenocarcinoma.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	34279-44-2
MW	288.25
Formula	C₁₅H₁₂O₆
SMILES	O=C1OC2(C=C(O)C(=O)C=C2C=3C=C(OC)C=C(O)C13)C
Target	Antibiotic,Apoptosis,DNA/RNA Synthesis

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Antibiotic,Apoptosis,DNA/RNA Synthesis

Protocol Information

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