DeFer-2

SKU: orb3136464

Description

DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 3058911-16-0
• MW: 780.11
• Formula: C₄₄H₆₉N₅O₅S
• SMILES: C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
• Target: PROTACs,ROS,Caspase,Pyroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,ROS,Caspase,Pyroptosis