Decamethonium bromide

SKU: orb1310265

Description

Decamethonium bromide (Syncurine) is a neuromuscular blocking agent that acts as a partial agonist of nicotinic acetylcholine receptors. It is used in research to study neuromuscular junction physiology and receptor pharmacology in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 541-22-0
• MW: 418.29
• Purity: 99.90% (May vary between batches)
• Formula: C₁₆H₃₈Br₂N₂
• SMILES: [Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
• Target: Cholinesterase (ChE),AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.78 mM);DMSO:65 mg/mL (155.39 mM);H2O:77 mg/mL (184.08 mM);Ethanol:24 mg/mL (57.38 mM)

Bioactivity

• In Vivo:
  At the motor neuromuscular endplate, Decamethonium induces a depolarization that prevents the normal release of acetylcholine from presynaptic terminals from acting further, thereby preventing the nerve stimulus from affecting the muscle. During binding, Decamethonium actually activates (depolarizes) the motor endplate, but does not degrade itself, so the cell membrane remains depolarized and unresponsive to normal acetylcholine release. As a depolarizing muscle relaxant or neuromuscular blocker, Decamethonium is used in anesthesia to induce paralysis. It has a short duration of action similar to that of acetylcholine and acts as a partial agonist at nicotinic acetylcholine-like receptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Syncurine, nAChR, Nicotinic acetylcholine receptors, inhibit, Inhibitor, Decamethonium, Decamethonium bromide, Decamethonium Bromide, Decacuran, AChE

Compound Identifiers

PubChem CID

10921