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DDO-4033

SKU: orb3136388

Description

DDO-4033 is an SPOP inhibitor with an IC50 of 16.9 μM and a Kd of 15.1 μM. It hinders the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts the recruitment of the substrate LATS1 by SPOP, inhibiting its polyubiquitination and subsequent degradation, which leads to the upregulation of LATS1 expression. This compound demonstrates significant antitumor activity and can be utilized in renal cell carcinoma research.

Research Area

Metabolism Research, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetE1/E2/E3 Enzyme,YAP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information