dCASP1-55

SKU: orb3210444

Description

dCASP1-55 is a cereblon-dependent PROTAC degrader targeting caspase-1 (CASP1). In leukemia cells, it induces excessive NF-κB activation, triggers apoptosis, and causes moderate S-phase arrest. dCASP1-55 also inhibits colony formation in leukemia cells. It is applicable for cancer research, including studies on myeloid malignancies and acute myeloid leukemia.

Key Properties

• Target: NF-κB,Caspase,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,Caspase,PROTACs,Apoptosis