DC_AC50

SKU: orb1217971

Description

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.

Key Properties

• CAS Number: 497061-48-0
• MW: 424.26
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₂BrF₂N₃OS
• SMILES: NC1=C(SC2=C1C=C3CCCC3=N2)C(NC4=C(Br)C=C(C=C4F)F)=O
• Target: Apoptosis
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells. Concentration: 0-10 μM. Incubation time: 72 h. Result: Dose-dependently decreased viability of OSA cells. Apoptosis Analysis Cell line: Abrams and HOS cells. Concentration: 1, 3 and 10 μM (10 μM Carboplatin). Incubation time: 24 h. Result: Potentiated carboplatin-induced apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis