DC661

SKU: orb1225839

Description

DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.

Key Properties

• CAS Number: 1872387-43-3
• MW: 550.612
• Purity: >98% (HPLC)
• Formula: C₃₃H₄₁Cl₂N₃
• SMILES: CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
• Target: Autophagy
• Solubility: DMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  DC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DC-661 | DC 661

Quick Database Links

Gene Symbol

Autophagy