DC-S239

SKU: orb1301233

Description

DC-S239 is a potent and selective small molecule inhibitor of the histone methyltransferase SETD7, exhibiting an IC50 of 4.59 µM. It is a valuable research tool for studying epigenetic regulation in oncology, with applications in both in vitro biochemical assays and cellular studies exploring its anticancer mechanisms.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 303141-21-1
• MW: 349.36
• Purity: 99.37% (May vary between batches)
• Formula: C₁₅H₁₅N₃O₅S
• SMILES: CCOC(=O)c1c(N)sc(C(=O)Nc2cccc(c2)[N+]([O-])=O)c1C
• Target: Histone Methyltransferase
• Solubility: DMSO:5.5 mg/mL (15.74 mM)

Bioactivity

• In Vitro:
  DC-S239 (0-100 μM) inhibits the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner with the IC50 values of 10.93 μM and 16.43 μM, respectively. DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, whereas it inhibits SET7 by 90% at concentrations of 100 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-cancer, DC-S 239, DC-S-239, Ethyl 2amino4methyl5[(3nitrophenyl)carbamoyl]thiophene3carboxylate, Ethyl 2 amino 4 methyl 5 [(3 nitrophenyl)carbamoyl]thiophene 3 carboxylate, Inhibitor, MCF7, Histone Methyltransferase, HistoneMethyltransferase, HL60, MV4-11, inhibit, SETD7, SET7 inhibitor

Compound Identifiers

PubChem CID

2258873