DC-PGKI

SKU: orb3174338

Description

DC-PGKI is an orally active ATP-competitive inhibitor of PGK1, with an IC50 of 0.16 μM and a Kd of 99.08 nM. It stabilizes PGK1 both in vitro and in vivo, inhibiting glycolytic activity and PGK1's kinase function. This inhibition induces the accumulation of NRF2 (nuclear factor erythroid 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and inhibits their LPS-induced expression. DC-PGKI is applicable for research in colitis.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2829198-49-2
• MW: 558.46
• Formula: C₂₆H₂₉Cl₂N₇O₃
• SMILES: O=C(OCC)C1=NC=2C=C(Cl)C(Cl)=CC2N=C1N3CCN(C(=O)NC4=CC=C(C=C4)N5CCNCC5)CC3
• Target: Nrf2,PGK1,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Nrf2,PGK1,Interleukin