DBPR112 HCl

SKU: orb1739982

Description

DBPR112 is a clinical candidate EGFR inhibitor with potent activity against resistant mutations, including L858R/T790M and exon 20 insertions, outperforming osimertinib in vitro. It demonstrates favorable oral pharmacokinetics, significant in vivo antitumor efficacy in xenograft models, and a promising safety profile for non-small cell lung cancer research.

Key Properties

• CAS Number: 2889316-21-4
• MW: 570.08
• Formula: C₃₂H₃₂ClN₅O₃
• SMILES: N([C@H](CO)C1=CC=CC=C1)C2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC(NC(/C=C/CN(C)C)=O)=CC=C5.Cl
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652785