DB21, Galectin-1 Antagonist

SKU: orb1942165

Description

DB21 is a peptidomimetic dibenzofuran conjugate that functions as an allosteric galectin-1 (GAL1) inhibitor. It disrupts GAL1-glycan interactions, demonstrating anti-angiogenic and anti-tumor effects in preclinical models of melanoma, lung adenocarcinoma, and ovarian cancer in both in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• Target: Galectin
• CAS Number: 1623027-80-4
• MW: 1690.08
• Formula: C₈₃H₁₃₆N₁₈O₁₉
• SMILES: C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)C(C)C)=O)CCC(N)=O)=O)CCC)=O)CCCCN)=O)CC(C)C)=O)C1=C2C(C=3C(O2)=C(CCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)CCCCN)=O)[C@@H](C)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C=CC3)=CC=C1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361198